Fatal Sulfasalazine-Induced Eosinophilic Myocarditis in a Patient with Periodic Fever Syndrome

نویسندگان

  • Ivica Jeremic
  • Nada Vujasinovic-Stupar
  • Tatjana Terzic
  • Nemanja Damjanov
  • Milos Nikolic
  • Branka Bonaci-Nikolic
چکیده

OBJECTIVE The aim of this paper is to report the first case of drug-induced eosinophilic myocarditis (EM) in a patient with hereditary periodic fever syndrome (PFS). CASE A 28-year-old man with hyper-IgD syndrome, one of the PFS, developed a sulfasalazine-induced systemic hypersensitivity reaction complicated by EM. Thirteen days after sulfasalazine introduction, which had been given for arthritis, the patient developed fever, facial/neck edema, rash and cardiogenic shock, and died within 8 h. The autopsy revealed hemophagocytosis, while acute heart failure caused by necrotizing EM was established as the cause of death. CONCLUSION This was a case of drug-induced EM in a patient with PFS that had an atypical presentation, rapid evolution and poor outcome.

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عنوان ژورنال:

دوره 24  شماره 

صفحات  -

تاریخ انتشار 2015